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Genetics of Antibody Diversity and Function
Genetics of Antibody Diversity and Function Antibody genes are produced by somatic recombination The immunoglobulin repertoire is encoded for by multiple germline gene segments that undergo somatic diversification in developing B‐cells. Hence, although the basic components needed to generate an immunoglobulin repertoire are inherited, an individual’s mature antibody repertoire is essentially formed during their lifetime by alteration of the inherited germline genes. The first evidence that…
